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Gibco™ Human GDF-15/MIC-1 Recombinant Protein, PeproTech®
Recombinant Protein
642.00 DKK - 41290.00 DKK
Specifications
Accession Number | Q99988 |
---|---|
For Use With (Application) | Functional Assay |
Formulation | protein with no preservative |
Gene ID (Entrez) | 9518 |
Molecular Weight (g/mol) | 24.6 kDa |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
17810303
|
Gibco™
120-28C-100UG |
100 ÎĽg |
6760.00 DKK
100µg |
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17851533
|
Gibco™
120-28C-1MG |
1 mg |
41290.00 DKK
1mg |
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17860963
|
Gibco™
120-28C-20UG |
20 ÎĽg |
1556.00 DKK
20µg |
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17860573
|
Gibco™
120-28C-250UG |
250 ÎĽg |
14520.00 DKK
250µg |
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17820973
|
Gibco™
120-28C-500UG |
500 ÎĽg |
24810.00 DKK
500µg |
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17861363
|
Gibco™
120-28C-5UG |
5 ÎĽg |
642.00 DKK
5µg |
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Description
Recombinant Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 112 amino acid polypeptide chains. The calculated molecular weight of Recombinant Human GDF-15/MIC-1 is 24.6 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
GDF-15 belongs to the TGF-beta cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.Specifications
Q99988 | |
protein with no preservative | |
24.6 kDa | |
CHO cells | |
<1 EU/ ÎĽg | |
GDF15 | |
Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1 osteoblastcells. The expected ED50 for this effect is 75-200 ng/ml | |
Recombinant | |
-20°C | |
Lyophilized |
Functional Assay | |
9518 | |
Human GDF-15/MIC-1 | |
RUO | |
Gdf15; GDF-15; growth differentiation factor 15; growth/differentiation factor 15; macrophage inhibiting cytokine-1; macrophage inhibitory cytokine 1; MIC1; MIC-1; NAG1; NAG-1; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; PLAB; Placental bone morphogenetic protein; placental TGF-beta; Prostate differentiation factor; PTGFB; PTGF-beta; SBF | |
Gdf15 | |
Unconjugated | |
ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI | |
CHO cells | |
≥ 95% by SDS-PAGE gel and HPLC analyses. |
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