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Gibco™ Human GDF-15/MIC-1 Recombinant Protein, PeproTech®

Recombinant Protein

642.00 DKK - 41290.00 DKK

Specifications

Accession Number Q99988
For Use With (Application) Functional Assay
Formulation protein with no preservative
Gene ID (Entrez) 9518
Molecular Weight (g/mol) 24.6 kDa
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Products 6
Product Code Brand Quantity Price Quantity & Availability  
Product Code Brand Quantity Price Quantity & Availability  
17810303
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Gibco™
120-28C-100UG
100 ÎĽg
6760.00 DKK
100µg
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17851533
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Gibco™
120-28C-1MG
1 mg
41290.00 DKK
1mg
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17860963
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Gibco™
120-28C-20UG
20 ÎĽg
1556.00 DKK
20µg
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17860573
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Gibco™
120-28C-250UG
250 ÎĽg
14520.00 DKK
250µg
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17820973
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Gibco™
120-28C-500UG
500 ÎĽg
24810.00 DKK
500µg
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17861363
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Gibco™
120-28C-5UG
5 ÎĽg
642.00 DKK
5µg
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Description

Description

Recombinant Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 112 amino acid polypeptide chains. The calculated molecular weight of Recombinant Human GDF-15/MIC-1 is 24.6 kDa. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

GDF-15 belongs to the TGF-beta cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.
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