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Gibco™ Human FGF-basic (FGF-2/bFGF) (aa 10-155) Recombinant Protein

Artikelnummer. 10622074
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Mængde:
1 mg
10 μg
100 μg
50 μg
Pakningsstørrelse:
100µg
50µg
Hver
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Artikelnummer. 10622074

Brand: Gibco™ PHG0024

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Beskrivelse

Recombinant Protein

Carrier-Free Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Reconstitute the lyophilized protein in sterile, distilled water to 0.1-0.5 mg/mL. Apportion the reconstituted protein into working aliquots and store at ≤-20°C. Make any further dilutions of the reconstituted protein in medium or buffered solution containing carrier protein, such as PBS with 0.1% BSA. Storage: Store the lyophilized protein at 2-8°C, preferably desiccated. Upon reconstitution, apportion into working aliquots and store at ≤-20°C (not in a frost-free freezer). Avoid repeated freeze-thaw cycles.

FGF2 (FGFb, fibroblast growth factor basic) belongs to the fibroblast growth factor (FGF) family, and interacts with high-affinity transmembrane receptors to influence cell proliferation and tissue neovascularization. FGF2 exists as five isoforms with distinct intracellular localizations and functions. The 18 kDa isoform is predominantly cytosolic and acts through cell surface receptors, whereas the 22, 22.5, 24 and 34 kDa isoforms are nuclear and may signal independent of transmembrane receptor pathways. In humans, the gene is located on the q arm of chromosome 4. FGF2 has been implicated in diverse biological processes, such as limb and nervous system development, wound healing, and tumor growth. The mRNA for FGF2 contains multiple polyadenylation sites, and is alternatively translated from non-AUG and AUG initiation codons, resulting in five different isoforms with distinct properties. The CUG-initiated isoforms are localized in the nucleus and are responsible for the intracrine effect, whereas, the AUG-initiated form is mostly cytosolic and is responsible for the paracrine and autocrine effects of this FGF. Diseases associated with FGF2 dysfunction include Kaposi Sarcoma and corneal neovascularization.
TRUSTED_SUSTAINABILITY

Tekniske data

Adgangsnummer P09038
Til brug med (applikation) Bioactivity
Formulering Protein with no preservative
Gen-id (Entrez) 2247
Molekylvægt (g/mol) 17 kDa
Navn Human FGF-basic (FGF-2/bFGF) (aa 10-155)
Oprensningsmetode Purified
Mængde 10 μg
Opbevaringskrav 4°C
Regulatorisk status RUO
Endotoksin koncentration <0.1 ng/μg
Gene Alias Basic fibroblast growth factor; basic fibroblast growth factor bFGF; bFGF; FGF; fgf basic; Fgf2; Fgf-2; Fgfb; FGF-b; Fibroblast growth factor; fibroblast growth factor 2; fibroblast growth factor 2 (basic); Fibroblast growth factor basic; HBGF-2; Heparin-binding growth factor 2; H-FGF-b-147; H-FGF-b-154; M-FGF-b; Prostatic growth factor; prostatropin
Fælles navn FGF2
Gen symbol FGF2
Biologisk aktivitet ED50 ≤ 1.0 ng/mL; determined by the dose-dependent proliferation of BALB/3T3 cells.
Produkttype Protein
Konjugeret Unconjugated
Arter Human
Rekombinant Recombinant
Sekvens Human FGF-basic, amino acids 10-155
Indhold og opbevaring 4°C
Aktivitet ED50 ≤ 1.0 ng/mL; determined by the dose-dependent proliferation of BALB/3T3 cells.
Endotoksin niveau <0.1 ng/μg
Forsendelsestilstand Approved for shipment on Wet or Dry Ice
Udtrykssystem E. coli
Protein familie Growth Factors & Receptors
Protein form Recombinant, Ligand, Truncated
Form Lyophilized
Protein undertype FGFs (Fibroblast Growth Factors)
Forskningskategori Neurobiology, Oncology, Stem Cell Research, Microbiology, Differentiation, Angiogenesis
Produktlinje Gibco
Renhed eller kvalitetsklasse >95% by SDS-PAGE
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