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Glimepiride

Artikelnummer. 15484489
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Mængde:
100 mg
1 g
Pakningsstørrelse:
100mg
1g
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Artikelnummer. 15484489 Leverandør Thermo Scientific Alfa Aesar Leverandørnr. J62032.MC
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Beskrivelse

A sulfonylurea hypoglecemic agent and potent potassium channel blocker | CAS: 93479-97-1 | C24H34N4O5S | 490.62 g/mol

Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Glimepiride induces the PI3 kinase (PI3K) and Akt pathway, along with insulin receptor substrate-1/2 and endothelial nitric oxide synthase. Glimepiride also increases osteoblast proliferation and differentiation, which is thought to be related to its ability to activate the PI3K and Akt pathway. Furthermore, Glimepiride enhances intrinsic peroxisome proliferator-activated receptor γ activity. Glimepiride also increases protein expression of glucose transports 1 and 4, and is a potent KIR channel blocker. Potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

Solubility
Soluble in DMSO

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 93479-97-1
Molekylær formel C24H34N4O5S
Molekylvægt (g/mol) 490.62
MDL nummer MFCD00878417
InChI nøgle WIGIZIANZCJQQY-UHFFFAOYSA-N
Synonym glimepiride, amaryl, glimepiridum, glimepirida, amarel, glimepirid, glimepride, endial, roname, glimepiridum latin
PubChem CID 3476
IUPAC navn 3-ethyl-4-methyl-N-{2-[4-({[(4-methylcyclohexyl)carbamoyl]amino}sulfonyl)phenyl]ethyl}-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide
SMIL CCC1=C(C)CN(C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC2CCC(C)CC2)C1=O

Tekniske data

Kemisk navn eller materiale Glimepiride
Smeltepunkt 212°C to 215°C
Farve White
Mængde 100 mg
Merck Index 14,4440
Opløselighedsinformation Soluble in DMSO
Formel vægt 490.62
Fysisk form Powder

RUO – Research Use Only

Produkttitel
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