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Gefitinib hydrochloride, MedChemExpress

Artikelnummer. 16497886
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Artikelnummer. Mængde
16497886 100 mg
16441949 1 g
16401936 500 mg
16490588 5 g
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Artikelnummer. 16497886 Leverandør Medchem Express Leverandørnr. HY50895A

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Beskrivelse

MedChemExpress Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib hydrochloride selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib hydrochloride also induces autophagy. Gefitinib hydrochloride has antitumour activity.

Gefitinib hydrochloride (ZD1839 hydrochloride) is a potent, selective and orally active EGFR tyrosine kinase inhibitor with an IC50 of 33 nM. Gefitinib hydrochloride selectively inhibits EGF-stimulated tumor cell growth (IC50 of 54 nM) and that blocks EGF-stimulated EGFR autophosphorylation in tumor cells. Gefitinib hydrochloride also induces autophagy. Gefitinib hydrochloride has antitumour activity.

Tekniske data

Kemisk navn eller materiale Gefitinib hydrochloride
CAS 184475-55-6
Farve Off-White
Renhedsgrad noter Research
Molekylær formel C22H25Cl2FN4O3
Mængde 100 mg
Synonym ZD-1839 hydrochloride
Opløselighedsinformation H2O : 6.25 mg/mL (12.93 mM; Need ultrasonic) ∣DMSO : 0.227 mg/mL (0.47 mM; Need ultrasonic and warming)
SMIL ClC1=C(C=CC(NC2=NC=NC3=C2C=C(C(OC)=C3)OCCCN4CCOCC4)=C1)F.[H]Cl
Molekylvægt (g/mol) 483.36
Formel vægt 483.36
Procent renhed 99.8%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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