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Fluconazole, 99%, Thermo Scientific™
Fluconazole, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase.
Brand: Thermo Scientific Alfa Aesar J62015.03
| Mængde | 1g |
|---|
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Beskrivelse
This Thermo Scientific brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific.
General Description
• Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species
• It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity
• It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)
• Mammalian cell demethylation is much less susceptible to fluconazole inhibition
Applications
• Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.
• Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene
• In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays
• It has also been used as a positive control in antifungal assay of plants
Kemiske identifikatorer
| 86386-73-4 | |
| 306.277 | |
| RFHAOTPXVQNOHP-UHFFFAOYSA-N | |
| 3365 | |
| 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol |
| C13H12F2N6O | |
| MFCD00274549 | |
| fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol | |
| CHEBI:46081 | |
| C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O |
Tekniske data
| Fluconazole | |
| 1.05 | |
| MFCD00274549 | |
| 14,4122 | |
| Soluble indimethylsulfoxide and ethanol. | |
| C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O | |
| 306.277 | |
| CHEBI:46081 | |
| 99% |
| 86386-73-4 | |
| C13H12F2N6O | |
| 1g | |
| fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol | |
| RFHAOTPXVQNOHP-UHFFFAOYSA-N | |
| 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol | |
| 3365 | |
| 306.27 |
Sikkerhed og håndtering
Produktidentifikator
Signalord
Farekategori
Faresætning
Sikkerhedssætning
Supplerende oplysninger
- Fluconazole
Signalord
- Fare
Farekategori
- Akut toksicitet Kategori 4
- Alvorlige øjenskader/øjenirritation Kategori 2
- Reproduktionstoksicitet Kategori 1B
- Hudætsning/hudirritation Kategori 2
- Specifik målorgantoksicitet efter enkelt eksponering Kategori 2
Faresætning
- H302-Farlig ved indtagelse.
- H315-Forårsager hudirritation.
- H319-Forårsager alvorlig øjenirritation.
- H360D-Kan skade det ufødte barn.
- H371-Kan forårsage organskader.
Sikkerhedssætning
- P280-Bær beskyttelseshandsker/beskyttelsestøj/øjenbeskyttelse/ ansigtsbeskyttelse.
- P301+P330+P331-I TILFÆLDE AF INDTAGELSE: Skyl munden. Fremkald IKKE opkastning.
- P302+P352-VED KONTAKT MED HUDEN: Vask med rigeligt vand/.
- P305+P351+P338-VED KONTAKT MED ØJNENE: Skyl forsigtigt med vand i flere minutter. Fjern eventuelle kontaktlinser, hvis dette kan gøres let. Fortsæt skylning.
- P312-I tilfælde af ubehag, ring til en GIFTINFORMATION/læge/ .
Supplerende oplysninger
- MIXTURE LIST-Contain: Fluconazole
Produkttitel
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