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Fluconazole, 99%

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Artikelnummer. 15454479 Leverandør Thermo Scientific Alfa Aesar Leverandørnr. J62015.03
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Beskrivelse

Fluconazole, CAS # 86386-73-4, is a synthetic triazole with antifungal activity against some species of Candida. It also shows inhibitory activity against cytochrome P-450 enzymes and it is a demethylase. | CAS: 86386-73-4 | C13H12F2N6O | 306.277 g/mol

Fluconazole is used to treat a variety of fungal infections, especially Candida infections of the vagina (yeast infections), mouth, throat and bloodstream. It is also used by the people having weak immune system such as persons with neutropenia due to cancer chemotherapy, transplanted patients and premature infants.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Fluconazole, 98% is a triazole compound showing antifungal activity mainly against Candida, Coccidioides, and Cryptococcus species
  • It has been shown to inhibit fungal cytochrome P-450 sterol C-14 α-demethylation, resulting in the accumulation of fungal 14 α-methyl sterols, the loss of normal fungal sterols, and associated fungistatic activity
  • It also inhibits cytochrome P450 family 2 subfamily c member 9 (CYP2C9)
  • Mammalian cell demethylation is much less susceptible to fluconazole inhibition

Applications

  • Fluconazole has fungistatic activity against many fungal strains including Candida albicans, Candida glabrata, Candida parapsilosis, Candida tropicalis, and Cryptococcus neoformans.
  • Fluconazole interferes with fungal ergosterol synthesis and downregulates the metallothionein gene
  • In biological experiments, this compound has been used to assess minimum inhibitory concentration in (MIC)-fungal assays
  • It has also been used as a positive control in antifungal assay of plants
TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 86386-73-4
Molekylær formel C13H12F2N6O
Molekylvægt (g/mol) 306.277
MDL nummer MFCD00274549
InChI nøgle RFHAOTPXVQNOHP-UHFFFAOYSA-N
Synonym fluconazole, diflucan, triflucan, elazor, biozolene, biocanol, fungata, fluconazol, fluconazolum, flucazol
PubChem CID 3365
ChEBI CHEBI:46081
IUPAC navn 2-(2,4-difluorophenyl)-1,3-bis(1,2,4-triazol-1-yl)propan-2-ol
SMIL C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O

Specifications

Kemisk navn eller materiale Fluconazole
Smeltepunkt 138°C to 140°C
Farve White
Tæthed 1.05
Mængde 1 g
Merck Index 14,4122
Opløselighedsinformation Soluble indimethylsulfoxide and ethanol.
Formel vægt 306.27
Procent renhed 99%
Fysisk form Crystalline Powder

Safety and Handling

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Product Identifier
  • Fluconazole
 Signal Word
  • Fare
 Hazard Category
  • Akut toksicitet Kategori 4
  • Alvorlige øjenskader/øjenirritation Kategori 2
  • Reproduktionstoksicitet Kategori 1B
  • Hudætsning/hudirritation Kategori 2
  • Specifik målorgantoksicitet efter enkelt eksponering Kategori 2
 Hazard Statement
  • H302-Farlig ved indtagelse.
  • H315-Forårsager hudirritation.
  • H319-Forårsager alvorlig øjenirritation.
  • H360D-Kan skade det ufødte barn.
  • H371-Kan forårsage organskader.
 Precautionary Statement
  • P280-Bær beskyttelseshandsker/beskyttelsestøj/øjenbeskyttelse/ ansigtsbeskyttelse.
  • P301+P330+P331-I TILFÆLDE AF INDTAGELSE: Skyl munden. Fremkald IKKE opkastning.
  • P302+P352-VED KONTAKT MED HUDEN: Vask med rigeligt vand/.
  • P305+P351+P338-VED KONTAKT MED ØJNENE: Skyl forsigtigt med vand i flere minutter. Fjern eventuelle kontaktlinser, hvis dette kan gøres let. Fortsæt skylning.
  • P312-I tilfælde af ubehag, ring til en GIFTINFORMATION/læge/ .
 Supplemental information
  • MIXTURE LIST-Contain: Fluconazole

RUO – Research Use Only

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