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STEMCELL Technologies FK-866
Nicotinamide phosphoribosyltransferase inhibitor
1540.35 DKK - 2624.40 DKK
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
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17179981
|
STEMCELL Technologies
100-0263 |
5 mg |
1540.35 DKK
5mg |
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|
17189981
|
STEMCELL Technologies
100-0264 |
10 mg |
2624.40 DKK
10mg |
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Description
- FK-866 is a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme that regulates NAD+ biosynthesis from the natural precursor nicotinamide (Cameron et al.; Hasmann & Schemainda)
- In hepatocarcinoma cells, FK-866 activates AMP-activated protein kinase (AMPK) and downregulates mammalian target of rapamycin (mTOR) signaling (Schuster et al.)
- FK-866 can be used to deplete NAD+, a central metabolism cofactor (Cameron et al.; Hasmann & Schemainda; Jadeja et al.)
- Depletes NAD+ and induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 = ∼1 nM; Hasmann & Schemainda)
- Triggers dose-dependent cytotoxicity in multiple myeloma cells (Cea et al.)
- Induces autophagic death in neuroblastoma SH-SY5Y cells (IC50 = 0.93 nM; Billington et al.)
Specifications
| 658084-64-1 | |
| C24H29N3O2 | |
| ≥98% |
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Product Title
STEMCELL Technologies FK-866