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STEMCELL Technologies FK-866

Artikelnummer. 17189981
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Mængde:
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10 mg
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17189981 10 mg
17179981 5 mg
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Artikelnummer. 17189981 Leverandør STEMCELL Technologies Leverandørnr. 1000264

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Beskrivelse

Nicotinamide phosphoribosyltransferase inhibitor

  • FK-866 is a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme that regulates NAD+ biosynthesis from the natural precursor nicotinamide (Cameron et al.; Hasmann & Schemainda)
  • In hepatocarcinoma cells, FK-866 activates AMP-activated protein kinase (AMPK) and downregulates mammalian target of rapamycin (mTOR) signaling (Schuster et al.)
  • FK-866 can be used to deplete NAD+, a central metabolism cofactor (Cameron et al.; Hasmann & Schemainda; Jadeja et al.)
  • Depletes NAD+ and induces delayed cell death by apoptosis in HepG2 human liver carcinoma cells (IC50 = ∼1 nM; Hasmann & Schemainda)
  • Triggers dose-dependent cytotoxicity in multiple myeloma cells (Cea et al.)
  • Induces autophagic death in neuroblastoma SH-SY5Y cells (IC50 = 0.93 nM; Billington et al.)

Tekniske data

CAS 658084-64-1
Mængde 10 mg
Molekylær formel C24H29N3O2
Renhed ≥98%
Produkttitel
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