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Crizotinib, MedChemExpress

Artikelnummer. 16494037
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16494037 50 mg
16461926 500 mg
16461326 200 mg
16438128 10 mg
16437886 100 mg
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Artikelnummer. 16494037 Leverandør Medchem Express Leverandørnr. HY50878

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Beskrivelse

MedChemExpress Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition.

Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC50s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC50s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition.

Tekniske data

Kemisk navn eller materiale Crizotinib
CAS 877399-52-5
Farve Off-White
Renhedsgrad noter Research
Molekylær formel C21H22Cl2FN5O
Mængde 50 mg
Synonym PF-02341066
Opløselighedsinformation DMSO : 33.33 mg/mL (74.01 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic) (insoluble)
SMIL ClC1=C(F)C=CC(Cl)=C1[C@H](OC2=CC(C3=CN(N=C3)C4CCNCC4)=CN=C2N)C
Molekylvægt (g/mol) 450.34
Formel vægt 450.34
Procent renhed 97.05%
Grad Research
Fysisk form Powder
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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