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CGK 733, Tocris Bioscience™
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Artikelnummer. 18015522
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50 mg
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18015522 10 mg
18005622 50 mg
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Artikelnummer. 18015522 Leverandør Tocris Bioscience Leverandørnr. 2639/10

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Beskrivelse

Induces apoptosis in prematurely senescent cells

Originally defined as a selective inhibitor of ATR and ATM kinases. Induces cell death in prematurely senescent breast cancer cells. Decreases p21CIP1 levels in premature senescent MCF-7 and HCT-116 cells; also exhibits antiproliferative activity in a range of cancer cell lines. Blocks camptothecin -induced p53 phosphorylation and protects cells from camptothecin-induced apoptosis.
TRUSTED_SUSTAINABILITY

Kemiske identifikatorer

CAS 905973-89-9
Molekylær formel C23H18Cl3FN4O3S
Molekylvægt (g/mol) 555.83
InChI nøgle HLCDNLNLQNYZTK-UHFFFAOYSA-N
Synonym 2,2-diphenyl-n-2,2,2-trichloro-1-3-4-fluoro-3-nitrophenyl thioureido ethyl acetamide, 2,2-diphenyl-n-2,2,2-trichloro-1-4-fluoro-3-nitrophenyl carbamothioylamino ethyl acetamide, diphenyl acetamidotrichloroethyl fluoronitrophenyl thiourea, unii-l3dgz99qym, 2,2-diphenyl-n-2,2,2-trichloro-1-4-fluoro-3-nitrophenyl carbamothioyl amino ethyl acetamide, l3dgz99qym, d00pxo, diphenyl acetamidotrichloroethyl fluoronitrophenyl thiourea inci
PubChem CID 6605258
IUPAC navn 2,2-diphenyl-N-[2,2,2-trichloro-1-[(4-fluoro-3-nitrophenyl)carbamothioylamino]ethyl]acetamide
SMIL C1=CC=C(C=C1)C(C2=CC=CC=C2)C(=O)NC(C(Cl)(Cl)Cl)NC(=S)NC3=CC(=C(C=C3)F)[N+](=O)[O-]

Tekniske data

Kemisk navn eller materiale CGK 733
Mængde 10 mg
Formel vægt 555.84
Procent renhed >98%
Produkttitel
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