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CF53, MedChemExpress

Artikelnummer. 16470947
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16470947 50 mg
16464658 10 mg
16437377 5 mg
16435496 100 mg
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Artikelnummer. 16470947 Leverandør Medchem Express Leverandørnr. HY112610

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Beskrivelse

MedChemExpress CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. CF53 shows potent anti-tumor activity both in vitro and in vivo.

CF53 is a highly potent, selective and orally active inhibitor of BET protein, with a Ki of Kd of 2.2 nM and an IC50 of 2 nM for BRD4 BD1. CF53 binds to both the BD1 and BD2 domains of BRD2, BRD3, BRD4, and BRDT BET proteins with high affinities, very selective over non-BET bromodomain-containing proteins. CF53 shows potent anti-tumor activity both in vitro and in vivo.

Tekniske data

Kemisk navn eller materiale CF53
CAS 1808160-52-2
Farve Light Yellow
Renhedsgrad noter Research
Molekylær formel C24H25N7O2
Mængde 50 mg
Opløselighedsinformation DMSO : 110 mg/mL (248.03 mM; Need ultrasonic)
SMIL COC1=C(C2=C(C)ON=C2C)C=C(NC3=C4C(NC5=CC(C6CC6)=NN5C)=NC(C)=N3)C4=C1
Molekylvægt (g/mol) 443.5
Formel vægt 443.5
Procent renhed 98.09%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-programmed cell death
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Research purposes only

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