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Invitrogen™ Human CDK4/cyclin D3, GST Tag Recombinant Protein
Recombinant Protein
4385.00 DKK - 61400.00 DKK
Specifications
Accession Number | P11802 |
---|---|
Concentration | See Label |
For Use With (Application) | Kinase Assay |
Formulation | 50 mM tris HCl with 0.1 mM EDTA, 0.1 mM PMSF, 0.25 mM DTT, 10 mM glutathione, 150 mM NaCl, 25% glycerol and no preservative; pH 7.5 |
Gene ID (Entrez) | 1019 |
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
---|---|---|---|---|---|---|---|---|---|
Product Code | Brand | Quantity | Price | Quantity & Availability | |||||
15900423
|
Invitrogen™
A33515 |
10 ÎĽg |
4385.00 DKK
10µg |
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15990423
|
Invitrogen™
A33573 |
100 ÎĽg |
19780.00 DKK
100µg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
17188845
|
Invitrogen™
A33736 |
1 mg |
61400.00 DKK
1mg |
Please sign in to purchase this item. Need a web account? Register with us today! | |||||
Description
CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.Specifications
P11802 | |
Kinase Assay | |
1019 | |
Human CDK4/cyclin D3, GST Tag | |
CDK4 | |
Unconjugated | |
Recombinant | |
CDK4: 1-303, Cyclin D3: 1-292 | |
Dry Ice | |
Full Length, Recombinant, Active |
See Label | |
50 mM tris HCl with 0.1 mM EDTA, 0.1 mM PMSF, 0.25 mM DTT, 10 mM glutathione, 150 mM NaCl, 25% glycerol and no preservative; pH 7.5 | |
60.0-58.8 kDa | |
Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903) | |
CDKs and CHKs | |
Human | |
GST-tag | |
-80°C, Avoid Freeze/Thaw Cycles | |
Insect cells | |
Liquid |
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Product Title
Invitrogen™ Human CDK4/cyclin D3, GST Tag Recombinant Protein