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Invitrogen™ Human CDK4/cyclin D3, GST Tag Recombinant Protein
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Mængde:
1 mg
10 μg
100 μg
Pakningsstørrelse:
100µg
10µg
Beskrivelse
CDK4/cyclin D3 serine/threonine kinase is dimeric protein complex. CDK4 is a member of the cyclin-dependent protein kinase family and is involved in the control of cell proliferation during the G1 phase of cell cycle. CDK4 forms a complex with the D-type cyclins and is inhibited by p16 (cyclin-dependent kinase inhibitor-2). CDK4 can mediate phosphorylation of the C-terminal region of Rb protein leading to an active transcriptional repression of E2F complex. CDC37 and HSP90 can preferentially associate with the fraction of CDK4 not bound to D-type cyclins. SMAD3 is a major physiologic substrate of the G1 cyclin-dependent kinases CDK4 and CDK2. Although CDK6 and CDK4 can both phosphorylate multiple residues in the Rb protein, they do so with different residue selectivity in vitro; CDK6 phosphorylates Thr821 while CDK4 phosphorylates Thr826 on Rb protein.

Tekniske data
Tekniske data
Adgangsnummer | P11802 |
Koncentration | See Label |
Til brug med (applikation) | Kinase Assay |
Formulering | 50 mM tris HCl with 0.1 mM EDTA, 0.1 mM PMSF, 0.25 mM DTT, 10 mM glutathione, 150 mM NaCl, 25% glycerol and no preservative; pH 7.5 |
Gen-id (Entrez) | 1019 |
Molekylvægt (g/mol) | 60.0-58.8 kDa |
Navn | Human CDK4/cyclin D3, GST Tag |
Mængde | 100 μg |
Gene Alias | Cdk4; Cell division protein kinase 4; CMM3; Crk3; cyclin dependent kinase 4; cyclin-dependent kinase 4; MGC14458; PSK-J3; serine/threonine kinase; Unknown (protein for MGC:133903) |
Fælles navn | CDK4 |
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Produkttitel
Invitrogen™ Human CDK4/cyclin D3, GST Tag Recombinant Protein >
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