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BMS-599626 Hydrochloride, MedChemExpress

Artikelnummer. 16481157
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Mængde:
5 mg
50 mg
100 mg
Pakningsstørrelse:
5mg
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16481157 50 mg -
16417667 5 mg 5mg
16415696 100 mg -
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Artikelnummer. 16481157 Leverandør Medchem Express Leverandørnr. HY12010

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Beskrivelse

MedChemExpress BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ∼8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy.

BMS-599626 Hydrochloride (AC480 Hydrochloride) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. BMS-599626 Hydrochloride displays ∼8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. BMS-599626 Hydrochloride inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy.

Tekniske data

Kemisk navn eller materiale BMS-599626 Hydrochloride
CAS 873837-23-1
Farve White
Renhedsgrad noter Research
Molekylær formel C27H28ClFN8O3
Mængde 50 mg
Synonym AC480 Hydrochloride
Opløselighedsinformation DMSO : 100 mg/mL (176.36 mM; Need ultrasonic)
SMIL O=C(OC[C@H]1NCCOC1)NC2=CN(C3=C2C)N=CN=C3NC4=CC5=C(C=C4)N(CC6=CC(F)=CC=C6)N=C5.Cl
Molekylvægt (g/mol) 567.01
Formel vægt 567.01
Procent renhed 99.87%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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