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AZ304, MedChemExpress

Artikelnummer. 16435656
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Artikelnummer. Mængde
16435656 100 mg
16431127 50 mg
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Artikelnummer. 16435656 Leverandør Medchem Express Leverandørnr. HY117273

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Beskrivelse

MedChemExpress AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 (IC50, 6 nM), CSF1R (IC50, 35 nM). Anti-tumor activity.

AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 (IC50, 6 nM), CSF1R (IC50, 35 nM). Anti-tumor activity.

Tekniske data

Kemisk navn eller materiale AZ304
CAS 942507-42-8
Farve White
Renhedsgrad noter Research
Molekylær formel C27H25N5O2
Mængde 100 mg
Opløselighedsinformation DMSO : 125 mg/mL (276.84 mM; Need ultrasonic)
SMIL O=C(NC1=CC=C(C)C(NC2=C3C=CC(OC)=CC3=NC=N2)=C1)C4=CC=CC(C(C)(C#N)C)=C4
Molekylvægt (g/mol) 451.52
Formel vægt 451.52
Procent renhed 99.96%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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