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AX-024, MedChemExpress

Artikelnummer. 16482956
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Mængde:
2 mg
5 mg
10 mg
25 mg
50 mg
100 mg
Pakningsstørrelse:
10mg
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Artikelnummer. Mængde unitSize
16482956 25 mg -
16470477 50 mg -
16406827 5 mg -
16405096 100 mg -
16404128 10 mg 10mg
16400126 2 mg -
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Artikelnummer. 16482956 Leverandør Medchem Express Leverandørnr. HY107390

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Beskrivelse

MedChemExpress AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ∼1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.

AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC50 ∼1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, IL-10 and IL-17A.

Tekniske data

Kemisk navn eller materiale AX-024
CAS 1370544-73-2
Farve Light Yellow
Renhedsgrad noter Research
Molekylær formel C21H22FNO2
Mængde 25 mg
Opløselighedsinformation Ethanol : 100 mg/mL (294.64 mM; Need ultrasonic) ∣DMSO : 35 mg/mL (103.12 mM; Need ultrasonic and warming)
SMIL COC1=CC=C(OC2)C(C(C3=CC=C(F)C=C3)=C2CN4CCCC4)=C1
Molekylvægt (g/mol) 339.4
Formel vægt 339.4
Procent renhed 98.0%
Grad Research
Fysisk form Powder
Til brug med (applikation) COVID-19-immunoregulation
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Research purposes only

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