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Alisertib, MedChemExpress

Artikelnummer. 16497037
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Mængde:
5 mg
10 mg
50 mg
100 mg
200 mg
Pakningsstørrelse:
200mg
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Artikelnummer. Mængde unitSize
16497037 5 mg -
16495236 100 mg -
16471006 200 mg 200mg
16470647 50 mg -
16414328 10 mg -
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Product Code. 16497037 Supplier Medchem Express Supplier No. HY10971

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Description

MedChemExpress Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity.

Alisertib (MLN 8237) is an orally active and selective Aurora A kinase inhibitor (IC50=1.2 nM), which binds to Aurora A kinase resulting in mitotic spindle abnormalities, mitotic accumulation. Alisertib (MLN 8237) induces apoptosis and autophagy through targeting the AKT/mTOR/AMPK/p38 pathway in leukemic cells. Antitumor activity.

Specifications

Kemisk navn eller materiale Alisertib
CAS 1028486-01-2
Farve Light Nude
Renhedsgrad noter Research
Molekylær formel C27H20ClFN4O4
Mængde 5 mg
Synonym MLN 8237
Opløselighedsinformation DMSO : 25 mg/mL (48.18 mM; Need ultrasonic)
SMIL O=C(C1=CC=C(C=C1OC)NC2=NC=C3CN=C(C4=CC(Cl)=CC=C4C3=N2)C5=C(C=CC=C5F)OC)O
Molekylvægt (g/mol) 518.92
Formel vægt 518.92
Procent renhed 95.0%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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