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Abrocitinib, MedChemExpress

Artikelnummer. 16496827
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10 mg
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Artikelnummer. Mængde
16496827 5 mg
16484128 10 mg
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Artikelnummer. 16496827 Leverandør Medchem Express Leverandørnr. HY107429

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Beskrivelse

MedChemExpress Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease.

Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease.

Tekniske data

Kemisk navn eller materiale Abrocitinib
CAS 1622902-68-4
Farve Yellow
Renhedsgrad noter Research
Molekylær formel C14H21N5O2S
Mængde 5 mg
Synonym PF-04965842
Opløselighedsinformation DMSO : 125 mg/mL (386.51 mM; Need ultrasonic)
SMIL CN([C@H]1C[C@@H](NS(CCC)(=O)=O)C1)C2=C3C(NC=C3)=NC=N2
Molekylvægt (g/mol) 323.41
Formel vægt 323.41
Procent renhed 99.04%
Grad Research
Fysisk form Solid
Til brug med (applikation) COVID-19-immunoregulation
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Research purposes only

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