CAS RN 196868-63-0

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Tocris PQ 401, Tocris Bioscience™

CAS: 196868-63-0 Molecular Formula: C18H16ClN3O2 Molecular Weight (g/mol): 341.80 MDL Number: MFCD00160558 InChI Key: YBLWOZUPHDKFOT-UHFFFAOYSA-N Synonym: igf-1r inhibitor ii,1-5-chloro-2-methoxyphenyl-3-2-methylquinolin-4-yl urea,unii-2n3lv83s8j,n-5-chloro-2-methoxyphenyl-n'-2-methyl-4-quinolinyl urea,n-2-methoxy-5-chlorophenyl-n′-2-methylquinolin-4-yl-urea,d0b4su,urea, n-5-chloro-2-methoxyphenyl-n'-2-methyl-4-quinolinyl,pq hplc , powder,3-5-chloro-2-methoxyphenyl-1-2-methylquinolin-4-yl urea,n-2-methoxy-5-chlorophenyl-n'-2-methylquinolin-4-yl-urea PubChem CID: 9549305 IUPAC Name: 1-(5-chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea SMILES: COC1=C(NC(=O)NC2=C3C=CC=CC3=NC(C)=C2)C=C(Cl)C=C1

Pricing and Availability
Specifications

PubChem CID	9549305
CAS	196868-63-0
Molecular Weight (g/mol)	341.80
MDL Number	MFCD00160558
SMILES	COC1=C(NC(=O)NC2=C3C=CC=CC3=NC(C)=C2)C=C(Cl)C=C1
Synonym	igf-1r inhibitor ii,1-5-chloro-2-methoxyphenyl-3-2-methylquinolin-4-yl urea,unii-2n3lv83s8j,n-5-chloro-2-methoxyphenyl-n'-2-methyl-4-quinolinyl urea,n-2-methoxy-5-chlorophenyl-n′-2-methylquinolin-4-yl-urea,d0b4su,urea, n-5-chloro-2-methoxyphenyl-n'-2-methyl-4-quinolinyl,pq hplc , powder,3-5-chloro-2-methoxyphenyl-1-2-methylquinolin-4-yl urea,n-2-methoxy-5-chlorophenyl-n'-2-methylquinolin-4-yl-urea
IUPAC Name	1-(5-chloro-2-methoxyphenyl)-3-(2-methylquinolin-4-yl)urea
InChI Key	YBLWOZUPHDKFOT-UHFFFAOYSA-N
Molecular Formula	C18H16ClN3O2

Medchem Express PQ401, MedChemExpress

MedChemExpress PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC50 of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC50, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis.

Pricing and Availability
Specifications

Molecular Weight (g/mol)	341.79
Color	White
Physical Form	Solid
Chemical Name or Material	PQ401
Grade	Research
SMILES	O=C(NC1=CC(C)=NC2=CC=CC=C12)NC3=C(OC)C=CC(Cl)=C3
For Use With (Application)	Cancer-Kinase/protease
Percent Purity	99.88%
CAS	196868-63-0
Solubility Information	DMSO : 14.29 mg/mL (41.81 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Health Hazard 1	H302∣H315∣H319∣H335
Purity Grade Notes	Research
Recommended Storage	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Shelf Life	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molecular Formula	C₁₈H₁₆ClN₃O₂
Formula Weight	341.79

CAS RN 196868-63-0

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