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PQ401, MedChemExpress Product Code.: 16465808
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PQ401, MedChemExpress

Product Code. p-200101168
10 mg, 10mg
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Quantity:
10 mg
50 mg
Unit Size:
10mg
50mg
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Product Code. 16465808

Brand: Medchem Express HY13686

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Description

MedChemExpress PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC50 of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC50, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis.

PQ401 is a potent inhibitor of IGF-IR signaling. PQ401 inhibits IGF-I-stimulated IGF-IR autophosphorylation with an IC50 of 12.0 μM in a series of studies in MCF-7 cells. PQ401 is effective at inhibiting IGF-I-stimulated growth of MCF-7 cells (IC50, 6 μM). PQ401 is a potential agent for breast and other IGF-I-sensitive cancers. PQ401 induces caspase-mediated apoptosis.

Specifications

Chemical Name or Material PQ401
CAS 196868-63-0
Color White
Purity Grade Notes Research
Molecular Formula C18H16ClN3O2
Quantity 10 mg
Solubility Information DMSO : 14.29 mg/mL (41.81 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
SMILES O=C(NC1=CC(C)=NC2=CC=CC=C12)NC3=C(OC)C=CC(Cl)=C3
Molecular Weight (g/mol) 341.79
Formula Weight 341.79
Percent Purity 99.88%
Grade Research
Physical Form Solid
For Use With (Application) Cancer-Kinase/protease
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Research purposes only

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