CAS RN 905579-51-3

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Potent and selective NEDD8 activating enzyme (NAE) inhibitor; cell permeable

Kemisk navn eller materiale	[(1 S,2 S,4 R)-4-[4-[[(1 S)-2,3-Dihydro-1 H-inden-1-yl]amino]-7 H-pyrrolo[2,3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl sulfamic acid ester
Anbefalet opbevaring	Store at -20°C
CAS	905579-51-3
Mål	NEDD8 Activating Enzyme E1)
Renhed	0.98
Molekylær formel	C₂₁H₂₅N₅O₄S

MedChemExpress Pevonedistat (MLN4924) is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 4.7 nM.

Kemisk navn eller materiale	Pevonedistat
Formel vægt	443.52
Opløselighedsinformation	DMSO : 62.5 mg/mL (140.92 mM; Need ultrasonic)
Procent renhed	98.0%
Fysisk form	Solid
Farve	White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	443.52
CAS	905579-51-3
Synonym	MLN4924
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	O=S(OC[C@@H]1C[C@@H](N2C3=NC=NC(N[C@H]4CCC5=C4C=CC=C5)=C3C=C2)C[C@@H]1O)(N)=O
Renhedsgrad noter	Research
Molekylær formel	C₂₁H₂₅N₅O₄S
Til brug med (applikation)	Cancer-programmed cell death

Inhibits NEDD8-activating enzyme