CAS RN 871026-44-7

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MedChemExpress TAK-285 is a potent, selective, ATP-competitive and orally active HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, respectively. TAK-285 is >10-fold selectivity for HER1/2 than HER4, and less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. TAK-285 has effective antitumor activity. TAK-285 can cross the blood-brain barrier (BBB).

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	TAK-285
Formel vægt	547.96
Opløselighedsinformation	DMSO : ≥ 50 mg/mL (91.25 mM)
Procent renhed	95.0%
Fysisk form	Solid
Farve	Off-White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	547.96
CAS	871026-44-7
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	ClC(C=C(NC1=NC=NC2=C1N(CCNC(CC(C)(C)O)=O)C=C2)C=C3)=C3OC4=CC=CC(C(F)(F)F)=C4
Renhedsgrad noter	Research
Molekylær formel	C₂₆H₂₅ClF₃N₅O₃
Til brug med (applikation)	Cancer-Kinase/protease

CAS RN 871026-44-7

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