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TAK-285, MedChemExpress

Artikelnummer. 16496358
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16496358 10 mg
16488947 5 mg
16432477 50 mg
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Artikelnummer. 16496358 Leverandør Medchem Express Leverandørnr. HY15196

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Beskrivelse

MedChemExpress TAK-285 is a potent, selective, ATP-competitive and orally active HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, respectively. TAK-285 is >10-fold selectivity for HER1/2 than HER4, and less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. TAK-285 has effective antitumor activity. TAK-285 can cross the blood-brain barrier (BBB).

TAK-285 is a potent, selective, ATP-competitive and orally active HER2 and EGFR(HER1) inhibitor with IC50 of 17 nM and 23 nM, respectively. TAK-285 is >10-fold selectivity for HER1/2 than HER4, and less potent to MEK1/5, c-Met, Aurora B, Lck, CSK etc. TAK-285 has effective antitumor activity. TAK-285 can cross the blood-brain barrier (BBB).

Tekniske data

Kemisk navn eller materiale TAK-285
CAS 871026-44-7
Farve Off-White
Renhedsgrad noter Research
Molekylær formel C26H25ClF3N5O3
Mængde 10 mg
Opløselighedsinformation DMSO : ≥ 50 mg/mL (91.25 mM)
SMIL ClC(C=C(NC1=NC=NC2=C1N(CCNC(CC(C)(C)O)=O)C=C2)C=C3)=C3OC4=CC=CC(C(F)(F)F)=C4
Molekylvægt (g/mol) 547.96
Formel vægt 547.96
Procent renhed 95.0%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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