CAS RN 522-17-8
IUPAC Navn:
(1S,14S)-17,18-dimethoxy-7,7-dimethyl-2,8,21-trioxapentacyclo[12.8.0.0³,¹².0⁴,⁹.0¹⁵,²⁰]docosa-3(12),4(9),5,10,15(20),16,18-heptaen-13-one
Synonymer:
deguelin (-)-cis-deguelin
Molekylvægt (g/mol):
394.42
Molekylformel:
C23H22O6
InChi Key:
ORDAZKGHSNRHTD-UXHICEINSA-N
SMILES:
COC1=CC2=C(C=C1OC)[C@H]1[C@@H](CO2)OC2=C(C=CC3=C2C=CC(C)(C)O3)C1=O
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Resultater
1
Deguelin, TRC
CAS: 522-17-8 Molekylær formel: C23 H22 O6 Molekylvægt (g/mol): 394.42 Synonym: (7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one,(-)-Deguelin,(-)-cis-Deguelin; SMIL: COc1cc2OC[C@H]3Oc4c5C=CC(C)(C)Oc5ccc4C(=O)[C@H]3c2cc1OC
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Deguelin, MedChemExpress
MedChemExpress Deguelin, a naturally occurring rotenoid, acts as a chemopreventive agent by blocking multiple pathways like PI3K-Akt, IKK-NF-κB, and MAPK-mTOR-survivin-mediated apoptosis. Deguelin binding to Hsp90 leads to a decreased expression of numerous oncogenic proteins, including MEK1/2, Akt, HIF1α, COX-2, and NF-κB.
