CAS RN 2262452-06-0

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Tocris Bioscience™ RU.521

Potent and selective inhibitor of cyclic GMP-AMP synthase (cGAS)

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	3-[1-(6,7-Dichloro-1 H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1 H-pyrazol-4-yl]-1(3 H)-isobenzofuranone
Anbefalet opbevaring	Store at -20°C
CAS	2262452-06-0
Mål	Synthase/Synthetase Inhibitors
Renhed	0.98
Molekylær formel	C₁₉H₁₂Cl₂N₄O₃

MedChemExpress RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	RU.521
Sundhedsfare 1	H302∣H315∣H319∣H335
Formel vægt	415.23
Opløselighedsinformation	DMSO : 83.33 mg/mL (200.68 mM; Need ultrasonic)
Procent renhed	98.67%
Fysisk form	Solid
Farve	White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	415.23
CAS	2262452-06-0
Synonym	RU320521
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	O=C1OC(C2=C(O)N(C3=NC4=CC=C(Cl)C(Cl)=C4N3)N=C2C)C5=C1C=CC=C5
Renhedsgrad noter	Research
Molekylær formel	C₁₉H₁₂Cl₂N₄O₃
Til brug med (applikation)	Metabolism-protein/nucleotide metabolism

CAS RN 2262452-06-0

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Tocris Bioscience™ RU.521 Greener Choice ProductThis product offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”Learn More About the Greener Choice Program

Tocris Bioscience™ RU.521