CAS RN 1644545-52-7

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Vorasidenib, MedChemExpress

MedChemExpress Vorasidenib (AG-881) is an orally available, brain penetrant second-generation dual mutant isocitrate dehydrogenases 1 and 2 (mIDH1/2) inhibitor. Vorasidenib (AG-881) exhibits nanomolar inhibition of (D)-2-hydroxyglutarate (D-2-HG), and the IC50 ranges of 0.04∼22 nM against IDH1 R132C, IDH1 R132G, IDH1 R132H and IDH1 R132S and 7∼14 nM against IDH2 R140Q and 130 nM against IDH2 R172K.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Vorasidenib
Sundhedsfare 1	H302∣H315∣H319∣H335
Formel vægt	414.74
Opløselighedsinformation	DMSO : 100 mg/mL (241.11 mM; Need ultrasonic)
Procent renhed	99.3%
Fysisk form	Solid
Farve	White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	414.74
CAS	1644545-52-7
Synonym	AG-881
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	C[C@@H](NC1=NC(C2=NC(Cl)=CC=C2)=NC(N[C@H](C)C(F)(F)F)=N1)C(F)(F)F
Renhedsgrad noter	Research
Molekylær formel	C₁₄H₁₃ClF₆N₆
Til brug med (applikation)	Cancer-programmed cell death

CAS RN 1644545-52-7

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