MedChemExpress Rociletinib (CO-1686) is an orally delivered kinase inhibitor that specifically targets the mutant forms of EGFR including T790M, and the Ki values for EGFRL858R/T790M and EGFRWT are 21.5 nM and 303.3 nM, respectively.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Rociletinib
Formel vægt	555.55
Opløselighedsinformation	DMSO : ≥ 43 mg/mL (77.40 mM)
Procent renhed	98.12%
Fysisk form	Solid
Farve	Off-White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	555.55
CAS	1374640-70-6
Synonym	CO-1686 AVL-301 CNX-419
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	C=CC(NC1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C(C)=O)CC4)C=C3OC)=NC=C2C(F)(F)F)=C1)=O
Renhedsgrad noter	Research
Molekylær formel	C₂₇H₂₈F₃N₇O₃
Til brug med (applikation)	Cancer-Kinase/protease

CAS RN 1374640-70-6

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