CAS RN 1373615-35-0

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PF-5274857, MedChemExpress

MedChemExpress PF-5274857 is a potent, selective, orally active and brain-penetrant antagonist of Smo, with an IC50 of 5.8 nM and Ki of 4.6 nM. PF-5274857 has potential for research of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.

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Tekniske data

Kemisk navn eller materiale	PF-5274857
Formel vægt	436.96
Opløselighedsinformation	DMSO : 125 mg/mL (286.07 mM; Need ultrasonic) ∣H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)
Procent renhed	98.89%
Fysisk form	Solid
Farve	Yellow
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	436.96
CAS	1373615-35-0
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	O=C(N1CCN(C2=NC=C(Cl)C(C3=NC=C(C)C=C3C)=C2)CC1)CCS(=O)(C)=O
Renhedsgrad noter	Research
Molekylær formel	C₂₀H₂₅ClN₄O₃S
Til brug med (applikation)	Neuroscience-Neuromodulation

CAS RN 1373615-35-0

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