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CAS RN 1373423-53-0

IUPAC Navn: ethyl 3-{[2-(pyridin-2-yl)-6-(2,3,4,5-tetrahydro-1H-3-benzazepin-3-yl)pyrimidin-4-yl]amino}propanoate
Synonymer: ethyl 3-{[2-(pyridin-2-yl)-6-(1,2,4,5-tetrahydro-3-benzazepin-3-yl)pyrimidin-4-yl]amino}propanoate
Molekylvægt (g/mol): 417.51
Molekylformel: C24H27N5O2
InChi Key: WBKCKEHGXNWYMO-UHFFFAOYSA-N
SMILES: CCOC(=O)CCNC1=NC(=NC(=C1)N1CCC2=CC=CC=C2CC1)C1=CC=CC=N1

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1

Tocris Bioscience™ GSK J4
GREENER_CHOICE

CAS: 1373423-53-0 Molekylær formel: C24H27N5O2

CAS 1373423-53-0
Molekylær formel C24H27N5O2
2

GSK-J4, MedChemExpress

MedChemExpress GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable prodrug of GSK-J1. GSK-J4 induces endoplasmic reticulum stress-related apoptosis.

ENCOMPASS_PREFERRED
Kemisk navn eller materiale GSK-J4
Formel vægt 417.5
Opløselighedsinformation DMSO : ≥ 36 mg/mL (86.23 mM)
Procent renhed 95.0%
Fysisk form Oil
Farve Yellow
Grad Research
Anbefalet opbevaring Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol) 417.5
CAS 1373423-53-0
Holdbarhed Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL O=C(OCC)CCNC1=NC(C2=CC=CC=N2)=NC(N3CCC(C=CC=C4)=C4CC3)=C1
Renhedsgrad noter Research
Molekylær formel C24H27N5O2
Til brug med (applikation) Cancer-programmed cell death