CAS RN 1346546-69-7

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Tocris Bioscience™ GSK'872

Potent and selective RIP3 kinase inhibitor

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	N-5-Benzothiazolyl-6-[(1-methylethyl)sulfonyl]-4-quinolinamine
Anbefalet opbevaring	Store at -20°C
CAS	1346546-69-7
Formel vægt	383.49
Renhed	98%
Molekylær formel	C₁₉H₁₇N₃O₂S₂

MedChemExpress GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	GSK-872
Formel vægt	383.49
Opløselighedsinformation	DMSO : 100 mg/mL (260.76 mM; Need ultrasonic)
Procent renhed	98.0%
Fysisk form	Powder
Farve	Off-White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	383.49
CAS	1346546-69-7
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	O=S(C1=CC=C2N=CC=C(C2=C1)NC3=CC=C4SC=NC4=C3)(C(C)C)=O
Renhedsgrad noter	Research
Molekylær formel	C₁₉H₁₇N₃O₂S₂
Til brug med (applikation)	COVID-19-immunoregulation

CAS RN 1346546-69-7

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Tocris Bioscience™ GSK'872 Greener Choice ProductThis product offers one or more environmental benefits itemized in the U.S. FTC “Green Guides.”Learn More About the Greener Choice Program

Tocris Bioscience™ GSK'872