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GSK-872, MedChemExpress

Artikelnummer. 16490017
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16490017 50 mg -
16472796 25 mg -
16463628 10 mg -
16436357 5 mg -
16414716 100 mg 100mg
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Artikelnummer. 16490017 Leverandør Medchem Express Leverandørnr. HY101872

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Beskrivelse

MedChemExpress GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.

GSK-872 is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM. GSK-872 decreases the RIPK3-mediated necroptosis and subsequent cytoplasmic translocation and expression of HMGB1, as well as ameliorates brain edema and neurological deficits in early brain injury.

Tekniske data

Kemisk navn eller materiale GSK-872
CAS 1346546-69-7
Farve Off-White
Renhedsgrad noter Research
Molekylær formel C19H17N3O2S2
Mængde 50 mg
Opløselighedsinformation DMSO : 100 mg/mL (260.76 mM; Need ultrasonic)
SMIL O=S(C1=CC=C2N=CC=C(C2=C1)NC3=CC=C4SC=NC4=C3)(C(C)C)=O
Molekylvægt (g/mol) 383.49
Formel vægt 383.49
Procent renhed 98.0%
Grad Research
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Research purposes only

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