CAS RN 1108743-60-7

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Entrectinib, MedChemExpress

MedChemExpress Entrectinib (NMS-E628) is a potent, orally available, and CNS-active pan-Trk, ROS1, and ALK inhibitor. Entrectinib inhibits TrkA, TrkB, TrkC, ROS1 and ALK with IC50 values of 1, 3, 5, 12 and 7 nM, respectively. Antitumor activity.

Pris og tilgængelighed
Tekniske data

Kemisk navn eller materiale	Entrectinib
Sundhedsfare 1	H302∣H315∣H319∣H335
Formel vægt	560.64
Opløselighedsinformation	DMSO : ≥ 31 mg/mL (55.29 mM)
Procent renhed	98.13%
Fysisk form	Solid
Farve	Off-White
Grad	Research
Anbefalet opbevaring	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
Molekylvægt (g/mol)	560.64
CAS	1108743-60-7
Synonym	NMS-E628 RXDX-101
Holdbarhed	Powder -20°C 3 years, 4°C 2 years∣In solvent -80°C 6 months, -20°C 1 month
SMIL	O=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=C(NC5CCOCC5)C=C(N6CCN(C)CC6)C=C4
Renhedsgrad noter	Research
Molekylær formel	C₃₁H₃₄F₂N₆O₂
Til brug med (applikation)	Cancer-Kinase/protease

CAS RN 1108743-60-7

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