Aromatiske organiske heterocykliske forbindelser, der består af en femleddet ring med fire carbonatomer og et nitrogenatom, der danner en aminfunktionel gruppe.
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MedChemExpress Alosetron (GR 68755) is a potent and highly selective serotonin 5-HT3 receptor antagonist. Alosetron is used for the research of irritable bowel syndrome (IBS). Alosetron blocks the fast 5HT3-mediated depolarisation of guinea-pig myenteric and submucosal neurons, with IC50 at ∼55 nM. Alosetron attenuates the visceral nociceptive effect of rectal distension in conscious or anaesthetised dogs. Anti-inflammatory effects.
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