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Tocris Bioscience™ Zoledronic Acid, Tocris Bioscience™

Potent farnesyl diphosphate (FPP) synthase inhibitor
Brand: Tocris Bioscience™ 6111/10
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Beskrivelse
Zoledronic Acid is a potent bisphophonate farnesyl diphosphate (FPP) synthase inhibitor (IC50 = 20 nM). Inhibits osteoclast-mediated bone resorption. Also inhibits Ras signaling and tumor growth, and induces apoptosis in pancreatic cancer cells. Reverses epithelial-mesenchymal transition and inhibits breast cancer cell renewal via inactivation of NF-κB.Tekniske data
| Ras GTPase Inhibitors | |
| [1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid | |
| Soluble to 50mM in 1.1eq. NaOH and to 3mM in water | |
| Off-white |
| 118072-93-8 | |
| 10 mg | |
| Solid | |
| Bioactive Small Molecule |
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