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Invitrogen™ ZO-1 Monoclonal Antibody (ZO1-1A12)
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Artikelnummer. 10129012
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Mængde:
100 μg
Pakningsstørrelse:
Hver
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10129012 100 μg Hver
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Artikelnummer. 10129012 Leverandør Invitrogen™ Leverandørnr. 339100

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Mouse Monoclonal Antibody

33-9100 has been successfully used in ELISA, Immunofluorescence and Western Blot analysis of ZO-1.

ZO-1 forms complexes with either ZO-2 or ZO-3. In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. ZO-1 expression is significantly reduced in many breast cancer lines. ZO-2 and ZO-3 are ubiquitously expressed within epithelial tight junctions, and unlike ZO-1, which is also expressed at cell junctions of cardiac myocytes, ZO-2 is not expressed in nonepithelial tissue. ZO-1 is a protein located on a cytoplasmic membrane surface of intercellular tight junctions. ZO-1 may be involved in signal transduction at cell-cell junctions. Two transcript variants encoding distinct isoforms have been identified for the ZO-1 gene. Diseases associated with ZO-1 dysfunction include Celiac Disease and Congenital Nephrotic Syndrome.
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Tekniske data

Antigen ZO-1
Applikationer ELISA, Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry, Multiplex Immunohistochemistry
Klassifikation Monoclonal
Klon ZO1-1A12
Koncentration 0.5 mg/mL
Konjugeret Unconjugated
Formulering PBS with 0.1% sodium azide; pH 7.4
Gene TJP1
Genadgangsnr. O97758, P39447, Q07157
Gene Alias DKFZp686M05161; I79_005485; MGC133289; OTTHUMP00000174520; Tight junction protein 1; tight junction protein 1 (zona occludens 1); tight junction protein ZO-1; Tjp1; zo1; ZO-1; ZO-1 MDCK; zona occludens 1; zona occludens protein 1; zonula occludens 1; zonula occludens 1 protein; zonula occludens protein 1
Gensymboler TJP1
Værtsarter Mouse
Immunogen Human recombinant ZO-1 fusion protein encompassing amino acids 334-634.
Oprensningsmetode Affinity chromatography
Mængde 100 μg
Regulatorisk status RUO
Primær eller sekundær Primary
Gen-id (Entrez) 21872, 403752, 7082, 720550
Målarter Human, Mouse, Canine, Monkey, Rhesus Macaque
Indhold og opbevaring -20°C
Produkttype Antibody
Form Liquid
Isotype IgG1
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