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Tocris Bioscience™ ZNL 02-096
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Artikelnummer. 18738776
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1 mg
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18738776 1 mg
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Artikelnummer. 18738776 Leverandør Tocris Bioscience™ Leverandørnr. 7240/1

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Beskrivelse

Potent and selective Wee1 Degrader (PROTAC™)

ZNL 02-096 is a potent and selective Wee1 Degrader (PROTAC™) that comprises the Wee1 inhibitor AZD 1775 joined by a linker to the cereblon-binding ligand Pomalidomide (Cat. No. 6302). ZNL 02-096 selectively degrades Wee1 at submicromolar concentrations, while sparing PLK1, an AZD 1775 secondary target. In MOLT-4 cells in vitro, ZNL 02-096 induces degradation of Wee1, accumulation of DNA damage, arrest of the cell cycle in the G2/M phase and apoptosis. The compound shows antiproliferative effects in a panel of 300 cancer cell lines.

PROTAC™ is a registered trademark of Arvinas Operations, Inc., and is used under license.

TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1 H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
CAS 2414418-49-6
Mængde 1 mg
Mål Active Degraders
Molekylær formel C42H45N11O6
Renhed 0.98
Produkttitel
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