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STEMCELL Technologies (Z)-Guggulsterone

Artikelnummer. 17179971
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17179971 10 mg
17189971 50 mg
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Artikelnummer. 17179971 Leverandør STEMCELL Technologies Leverandørnr. 1000252

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Beskrivelse

Retinoic acid receptor (RAR) pathway inhibitor; Inhibits farnesoid X receptor (FXR)

  • (Z)-Guggulsterone is a plant steroid found in the resin of the guggul plant Commiphora mukul that acts as a selective antagonist of farnesoid X receptor (FXR; Cui et al.) It decreases chenodeoxycholic acid-induced FXR activation (IC50 = 10 μM) in the presence of 100 μM chenodeoxycholic acid (Cui et al.; Urizar et al.)
  • Induces differentiation of human pluripotent stem cell-derived neural stem cells into dopaminergic neurons (Gonzalez et al.)
  • Decreases hepatic low-density lipoprotein cholesterol and triglyceride levels in rodents fed with a high-cholesterol diet (Urizar et al.)
  • Regulates growth and metastasis of tumor cells in human multiple myeloma cells by the expression of STAT3-regulated antiapoptotic (Bcl-2, Bcl-xL, and Mcl-1), proliferative (cyclin D1), and angiogenic (VEGF) gene products (Ahn et al.)
  • Inhibits tube formation in human umbilical vein endothelial cells (HUVECs) and migration in HUVECs or a human prostate cancer cell line (Xiao et al.)

Tekniske data

CAS 39025-23-5
Mængde 10 mg
Molekylær formel C21H28O2
Renhed ≥98%
Produkttitel
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