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Tocris Bioscience™ Yoda 1
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Artikelnummer. 18775866
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18775866 10 mg
18756756 50 mg
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Artikelnummer. 18775866 Leverandør Tocris Bioscience™ Leverandørnr. 5586/10

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1561.34 DKK valid until 2026-06-30
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Beskrivelse

Piezo1 channel activator

Yoda 1 is a selective activator of mouse and human mechanosensitive channel piezo1. In HEK cells, Yoda 1 slows the inactivation phase of transient currents, sensitizes Piezo1 to activation by pressure, and partially activates channels in the absence of external pressure. In MDCK cells, Yoda 1 induces Ca2+-dependent chromatin hypercondensation and alters Ca2+-dependent myosin contractility, leading to nuclear shrinkage in cells. In red blood cells from sickle cell anemia (SCA) patients, Yoda 1 increases intracellular Ca2+ and phosphatidylserine exposure, which leads to KCa3.1 channel mediated Ca2+ influx and K+ and water efflux, causing shrinkage of the cells.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 2-[5-[[(2,6-Dichlorophenyl)methyl]thio]-1,3,4-thiadiazol-2-yl]pyrazine
CAS 448947-81-7
Mængde 10 mg
Mål Other Calcium Channel Activators
Molekylær formel C13H8Cl2N4S2
Formel vægt 355.27
Renhed >99%
Produkttitel
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