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Tocris Bioscience™ YM 254890
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Artikelnummer. 18739646
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Mængde:
1 mg
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18739646 1 mg
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Artikelnummer. 18739646 Leverandør Tocris Bioscience™ Leverandørnr. 7352/1

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Beskrivelse

Gα-protein inhibitor; potent inhibitor of Gq/11 signaling

YM 254890 is a Gα-protein inhibitor. Potently inhibits Gq/11 heterotrimeric G protein signaling. Inhibits ATP/UTP-induced Ca2+ increase in HCAE cells expressing P2Y2 receptor (IC50 = 50 nM); carbachol-induced production of IP1 in CHO cells expressing M1 receptor (IC50 = 95 nM); and ADP-induced Ca2+ increase in platelets, in vitro (IC50 = 2 μM). Also inhibits Gs-induced cAMP elevation and G protein-coupled MAPK/ERK signaling.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale (R)-1-((3 S,6 S,9 S,12 S,18 R,21 S,22 R)-21-acetamido-18-benzyl-3-((R)-1-methoxyethyl)-4,9,10,12,16,22-hexamethyl-15-methylene-2,5,8,11,14,17,20-heptaoxo-1,19-dioxa-4,7,10,13,16-pentaazacyclodocosan-6-yl)-2-methylpropyl (2 S,3 R)-2-acetamido-3-hydroxy-4-methylpent
CAS 568580-02-9
Mængde 1 mg
Mål GTPase Inhibitors
Molekylær formel C46H69N7O15
Renhed 0.95
Produkttitel
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