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XL019, MedChemExpress

Artikelnummer. 16468507
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16468507 5 mg
16426326 100 mg
16405858 10 mg
16402007 50 mg
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Artikelnummer. 16468507 Leverandør Medchem Express Leverandørnr. HY137755mg

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Beskrivelse

MedChemExpress XL019 is a potent, orally active, and selective JAK2 inhibitor, with IC50s of 2.2, 134.3, and 214.2 nM for JAK2, JAK1 and JAK3, respectively. XL019 shows 50-fold or greater selectivity for JAK2, versus a panel of over 100 serine/threonine and tyrosine kinases, including other members of the JAK family. XL019 potently inhibits STAT3 and STAT5 phosphorylation in cells harboring either JAK2V617F or wild-type JAK2.

XL019 is a potent, orally active, and selective JAK2 inhibitor, with IC50s of 2.2, 134.3, and 214.2 nM for JAK2, JAK1 and JAK3, respectively. XL019 shows 50-fold or greater selectivity for JAK2, versus a panel of over 100 serine/threonine and tyrosine kinases, including other members of the JAK family. XL019 potently inhibits STAT3 and STAT5 phosphorylation in cells harboring either JAK2V617F or wild-type JAK2.

Tekniske data

Kemisk navn eller materiale XL019
CAS 945755-56-6
Farve Green
Renhedsgrad noter Research
Molekylær formel C25H28N6O2
Mængde 5 mg
Opløselighedsinformation DMSO : 25 mg/mL (56.24 mM; Need ultrasonic)
SMIL O=C([C@H]1NCCC1)NC2=CC=C(C3=NC(NC4=CC=C(N5CCOCC5)C=C4)=NC=C3)C=C2
Molekylvægt (g/mol) 444.53
Formel vægt 444.53
Procent renhed 95.0%
Grad Research
Fysisk form Solid
Til brug med (applikation) Cancer-Kinase/protease
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Research purposes only

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