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Tocris Bioscience™ WS 6

Artikelnummer. 18024802
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10 mg
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Artikelnummer. Mængde
18024802 10 mg
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Artikelnummer. 18024802 Leverandør Tocris Bioscience™ Leverandørnr. 7791/10

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Beskrivelse

Induces growth and proliferation of pancreatic islet cells, murine totipotent stem cells, GABAergic neurons and hippocampal neurons

WS 6 induces growth and proliferation of cultured islet α and β cells in vitro (EC50 = 0.28 μM at β cells). Inhibits growth of FLT3-ITD+ AmL and K562 CmL cells (IC50 values are <0.24 nM and 40.48 nM, respectively). Reduces blood glucose in an animal model of type 1 diabetes. In combination with TTNPB (Cat. No. 0761) and 1-azakenpaullone, WS 6 induces and maintains murine totipotent stem cells. In an animal model of depression WS 6 induces dendrite complexity, enhances hippocampal neurogenesis, increases GABAergic neurons and GABA expression, and displays antidepressant and anxiolytic activity. WS 6 is predicted to be a receptor tyrosine kinase inhibitor.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 4-[[6-[(Cyclopropylcarbonyl)amino]-4-pyrimidinyl]oxy]-N-[4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)phenyl]benzeneacetamide
CAS 1421227-53-3
Mængde 10 mg
Mål Compounds for Stem Cell Proliferation and Renewal
Molekylær formel C29H31F3N6O3
Renhed 98%
Produkttitel
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