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Invitrogen™ WNK1 Polyclonal Antibody
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Artikelnummer. 13464779
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Mængde:
50 μg
Pakningsstørrelse:
50µg
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13464779 50 μg 50µg
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Artikelnummer. 13464779 Leverandør Invitrogen™ Leverandørnr. PA533110

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Beskrivelse

Rabbit Polyclonal Antibody

Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Bovine, Bat, Hamster, Elephant, Panda, Horse, Rabbit, Pig, Opossum, Turkey, Chicken (100%); Platypus, Xenopus (95%); Lizard (80%). For IHC(P), use heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen.

WNK1 serine/threonine kinase is a member of the WNK subfamily. WNK1 may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. WNK plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival, and proliferation. Also, acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, and SGK1. WNK localizes to a segment of kidney involved in salt, potassium, and pH homeostasis, the distal nephron. Mutations in the WNK gene result in Pseudohypaldosteronism and Neuropathy.
TRUSTED_SUSTAINABILITY

Tekniske data

Antigen WNK1
Applikationer ELISA, Immunohistochemistry (Paraffin)
Klassifikation Polyclonal
Koncentration 1 mg/mL
Konjugeret Unconjugated
Formulering PBS with 0.1% sodium azide
Gene WNK1
Genadgangsnr. P83741, Q6R2V0, Q9H4A3, Q9JIH7
Gene Alias 6430573H23Rik; EG406236; Erythrocyte 65 kDa protein; HSAN2; HSN2; hWNK1; KDP; KIAA0344; Kinase deficient protein; MGC163339; MGC163341; mKIAA0344; p65; PPP1R167; Prkwnk1; prostate-derived sterile 20-like kinase; protein kinase lysine-deficient 1; Protein kinase with no lysine 1; protein phosphatase 1, regulatory subunit 167; PSK; Serine/threonine-protein kinase WNK1; serine/threonine-protein kinase WNK1 1; serine/threonine-protein kinase WNK1 2; With no K; WNK lysine deficient protein kinase 1; WNK lysine deficient protein kinase 1 isoform; WNK1
Gensymboler WNK1
Værtsarter Rabbit
Immunogen Synthetic 20 amino acid peptide from internal region of human WNK1.
Oprensningsmetode Antigen affinity chromatography
Mængde 50 μg
Regulatorisk status RUO
Primær eller sekundær Primary
Gen-id (Entrez) 100350906, 116477, 232341, 406235, 427925, 506433, 65125
Målarter Human, Mouse, Rat, Rabbit, Monkey, Bovine, Hamster, Pig, Horse, Chicken, Bat
Indhold og opbevaring Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Produkttype Antibody
Form Liquid
Isotype IgG
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