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STEMCELL Technologies WHI-P131

Artikelnummer. 17130242
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Mængde:
1 mg
Pakningsstørrelse:
1mg
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Artikelnummer. 17130242 Leverandør STEMCELL Technologies Leverandørnr. 73542

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Beskrivelse

JAK/STAT pathway inhibitor; Inhibits JAK3

  • WHI-P131 is an inhibitor of Janus kinase 3 (JAK3) with IC50 values of 9 and 78 μM against human and mouse proteins, respectively (Sudbeck et al.) It has also been reported to show significant inhibition of other kinases, including epidermal growth factor receptor (EGFR) in the nanomolar range (Changelian et al.; Uckun et al.) No significant inhibition of JAK1 or JAK2 has been observed (Sudbeck et al.)
  • Induces apoptosis and cell death in human glioblastoma cell lines U373 and U87 (Narla et al.)
  • Inhibits lipopolysaccharide (LPS)-induced nitric oxide synthase expression and nitric oxide production in macrophages (Sareila et al.)
  • Inhibits proliferation of neural stem cell-containing neurospheres at lower concentrations than the concentration required to inhibit proliferation of astrocyte cultures (Diamandis et al.)

Tekniske data

CAS 202475-60-3
Synonym Janex-1
Mængde 1 mg
Molekylær formel C16H15N3O3
Renhed ≥98%
Produkttitel
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