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VPS34 Polyclonal Antibody, Invitrogen™
Rabbit Polyclonal Antibody
Brand: Invitrogen PA146456
This item is not returnable.
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Description
The target sequence has 87% sequence homology with xenopus. Suggested positive control: HepG2 whole cell lysates, antigen standard for PIK3C3 (transient overexpression lysate).
PIK3C3 (hVPS34) is the sole class III member of the PI3 Kinase family. PIK3C3 phosphorylates phosphatidylinositol (PI) to produce phosphatidylinositol 3-phosphate [PI(3)P], which recruits downstream effectors containing FYVE and Phox domains to membranes. PIK3C3 is involved in coupling nutrient signaling to mTOR and also plays a role in autophagy and intracellular trafficking. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes.
Specifications
| VPS34 | |
| Polyclonal | |
| Unconjugated | |
| Pik3c3 | |
| 5330434F23Rik; catalytic phosphatidylinositol 3-kinase 3; catalytic subunit type 3 Antibody; class 3 phosphoinositide-3-kinase; Class III PI 3-kinase; hVps34; hVps34 Antibody; OTTMUSP00000023341; OTTMUSP00000023350; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-kinase catalytic subunit type 3; phosphatidylinositol 3-kinase p100 subunit; phosphatidylinositol 3-kinase, catalytic subunit type 3; Phosphoinositide-3-kinase class 3; phosphoinositide-3-kinase, class 3; PI3K type 3; PI-3K Vps34p; pi3kc3; PI3-kinase type 3; Pik3c3; PIK3C3 Antibody; PtdIns-3-kinase type 3; VPS34 | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 225326, 503700, 5289, 65052 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunocytochemistry, Western Blot | |
| 0.2 mg/mL | |
| PBS with 0.1% BSA, 50% glycerol and 0.05% sodium azide | |
| O88763, Q5D891, Q6PF93, Q8NEB9 | |
| Pik3c3 | |
| Synthetic peptide made to an internal portion (within residues 700-850) of human VPS34. | |
| 100 μL | |
| Primary | |
| Human, Mouse, Porcine, Rat | |
| Antibody | |
| IgG |