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Tocris Bioscience™ VO-OHpic

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Mængde:
10 mg
50 mg
Beskrivelse
VO-OHpic is a potent inhibitor of PTEN (phosphatase and tensin homolog) (IC50 = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC50 values are 588 nM, 4.03, 57.5 and >10 μM respectively). Increases PIP2 and PIP3 levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated Tregs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.
Tekniske data
Tekniske data
| Mængde | 50 mg |
| Produkttype | VO-OHpic |
| Renhed | >98% |
| Molekylvægt (g/mol) | 361.16 |
| Inhibitorer | VO-OHpic |
For Research Use Only
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Produkttitel
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