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Invitrogen™ VHL Polyclonal Antibody

Rabbit Polyclonal Antibody
Brand: Invitrogen™ PA527322
Beskrivelse
Recommended positive controls: Myc-DDK-tagged VHL-transfected 293T. Predicted reactivity: Mouse (93%), Rat (91%), Dog (95%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Tekniske data
| VHL | |
| Polyclonal | |
| Unconjugated | |
| VHL | |
| elongin binding protein; HRCA1; Protein G7; pVHL; RCA1; VHL; VHL1; VHL19; Vhlh; VHLp18(MEA); Von Hippel Lindau; von hippel-lindau; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome homolog; von Hippel-Lindau syndrome protein homolog; von Hippel-Lindau tumor suppressor; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase | |
| Rabbit | |
| Antigen affinity chromatography | |
| RUO | |
| 22346, 7428 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry | |
| 0.6 mg/mL | |
| PBS with 20% glycerol and 0.025% ProClin 300; pH 7 | |
| P40337, P40338 | |
| VHL | |
| Recombinant protein encompassing a sequence within the center region of human Von Hippel Lindau. The exact sequence is proprietary. | |
| 100 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
Sikkerhed og håndtering
- VHL Polyclonal Antibody
Signalord
- Advarsel
Farekategori
- Hudsensibilisering Kategori 1
Faresætning
- H317-Kan forårsage allergisk hudreaktion.
Sikkerhedssætning
- P261-Undgå indånding af pulver/røg/gas/tåge/damp/spray.
- P272-Tilsmudset arbejdstøj bør ikke fjernes fra arbejdspladsen.
- P280-Bær beskyttelseshandsker/beskyttelsestøj/øjenbeskyttelse/ ansigtsbeskyttelse.
- P302+P352-VED KONTAKT MED HUDEN: Vask med rigeligt vand/.
- P333+P313-Ved hudirritation eller udslet: Søg lægehjælp.
- P501b-Indholdet/beholderen bortskaffes i henhold til de lokale/regionale/nationale/internationale forskrifter.
Supplerende oplysninger
- MIXTURE LIST-Indeholder: 5-chloro-2-methyl-3(2H)-isothiazolone
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