missing translation for 'onlineSavingsMsg'
Få mere at vide
Få mere at vide
Invitrogen™ VHL Polyclonal Antibody
Beskrivelse
Recommended positive controls: Myc-DDK-tagged VHL-transfected 293T. Predicted reactivity: Mouse (93%), Rat (91%), Dog (95%), Bovine (96%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Tekniske data
Tekniske data
| Antigen | VHL |
| Applikationer | Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot, Immunocytochemistry |
| Klassifikation | Polyclonal |
| Koncentration | 0.6 mg/mL |
| Konjugeret | Unconjugated |
| Formulering | PBS with 20% glycerol and 0.025% ProClin 300; pH 7 |
| Gene | VHL |
| Genadgangsnr. | P40337, P40338 |
| Gene Alias | elongin binding protein; HRCA1; Protein G7; pVHL; RCA1; VHL; VHL1; VHL19; Vhlh; VHLp18(MEA); Von Hippel Lindau; von hippel-lindau; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome homolog; von Hippel-Lindau syndrome protein homolog; von Hippel-Lindau tumor suppressor; von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase |
| Gensymboler | VHL |
| Vis mere |
Sikkerhed og håndtering
Produktidentifikator
- VHL Polyclonal Antibody
- Advarsel
- Hudsensibilisering Kategori 1
- H317-Kan forårsage allergisk hudreaktion.
- P261-Undgå indånding af pulver/røg/gas/tåge/damp/spray.
- P272-Tilsmudset arbejdstøj bør ikke fjernes fra arbejdspladsen.
- P280-Bær beskyttelseshandsker/beskyttelsestøj/øjenbeskyttelse/ ansigtsbeskyttelse.
- P302+P352-VED KONTAKT MED HUDEN: Vask med rigeligt vand/.
- P333+P313-Ved hudirritation eller udslet: Søg lægehjælp.
- P362+P364-Alt tilsmudset tøj tages af og vaskes inden genanvendelse.
- P501b-Indholdet/beholderen bortskaffes i henhold til de lokale/regionale/nationale/internationale forskrifter.
- MIXTURE LIST-Contain: 5-chloro-2-methyl-3(2H)-isothiazolone
Produkttitel
Ved at klikke på Send, anerkender du, at du kan blive kontaktet af Fisher Scientific med hensyn til den feedback, du har givet i denne formular. Vi deler ikke dine oplysninger til andre formål. Alle angivne kontaktoplysninger skal også vedligeholdes i overensstemmelse med vores Privatlivspolitik.
Ser du en mulighed for forbedring?