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STEMCELL Technologies Verteporfin

Artikelnummer. 17159981
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5 mg
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17159981 1 mg
17169981 5 mg
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Artikelnummer. 17159981 Leverandør STEMCELL Technologies Leverandørnr. 1000261

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Beskrivelse

YAP1 inhibitor

  • Verteporfin is a benzoporphyrin derivative that inhibits autophagosome formation by directly targeting and modifying p62, a scaffold protein that targets polyubiquitinated proteins for degradation (Donohue et al.) Verteporfin also disrupts YAP-TEAD interactions by enhancing trypsin cleavage of YAP (EC50 = 100 nM; Brodowska et al.; Liu-Chittenden et al.)
  • Inhibits the growth, proliferation, and viability of human retinoblastoma cells (Brodowska et al.)
  • Inhibits self-renewal in cancer stem cells with high YAP1 and ALDH1 levels (Song et al.)

Tekniske data

CAS 129497-78-5
Synonym BPD-MA; CL 318,952
Mængde 1 mg
Molekylær formel C41H42N4O8
Renhed ≥95%
Produkttitel
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