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Tocris Bioscience™ Verdinexor
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Artikelnummer. 18787586
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Mængde:
10 mg
50 mg
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Artikelnummer. Mængde
18787586 10 mg
18756696 50 mg
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Artikelnummer. 18787586 Leverandør Tocris Bioscience™ Leverandørnr. 7569/10

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Beskrivelse

Selective exportin-1 (XPO1/CRM1) inhibitor

Verdinexor is a selective exportin-1 (XPO1/CRM1) inhibitor. It potently inhibits influenza virus ribonucleoprotein (vRNP) export by disrupting XPO1-NEP binding and the replication of influenza virus A and B strains in vitro, including H1N1, H5N1 and H7N9 (IC50 values in the range 40 - 420 nM range). Verdinexor limits influenza A virus spread in mouse lung in vivo. In neuroblastoma, verdinexor suppresses cell proliferation and induces cell apoptosis. It also induces P53 nuclear accumulation and induces G0/G1 phase cell cycle arrest by activating P53 function. Verdinexor inhibits tumor growth in in vivo mouse models. Orally bioavailable.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale (2 Z)-3-[3-[3,5-Bis(trifluoromethyl)phenyl]-1 H-1,2,4-triazol-1-yl]-2-propenoic acid 2-(2-pyridinyl)hydrazide
CAS 1392136-43-4
Mængde 10 mg
Mål Antiviral Compounds
Molekylær formel C18H12F6N6O
Renhed 0.98
Produkttitel
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