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Tocris Bioscience™ Veliparib dihydrochloride
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Artikelnummer. 18717816
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Mængde:
50 mg
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18717816 50 mg
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Artikelnummer. 18717816 Leverandør Tocris Bioscience™ Leverandørnr. 7026/50

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Beskrivelse

High affinity PARP-1 and -2 inhibitor; orally bioavailable

Veliparib dihydrochloride is a high affinity PARP-2 and PARP-1 inhibitor (Ki values are 2.9 and 5.2 nM, respectively). Inhibits repair of radiation-induced DNA damage and sensitizes lung cancer cells to radiation. Also increases autophagy and apoptosis in lung cancer cells. Enhances radiation-induced tumor growth delay in mice bearing lung tumor xenografts. Also chemosensitizer. Potentiates effects of temozolomide (Cat. No. 2706) in a mouse melanoma model. Orally bioavailable and brain penetrant.
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Tekniske data

Kemisk navn eller materiale 2-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-4-carboxamide dihydrochloride
CAS 912445-05-7
Mængde 50 mg
Molekylær formel C13H16N4O.2HCl
Renhed 98%
Produkttitel
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