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Tocris Bioscience™ VAS 2870
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Artikelnummer. 18739126
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Mængde:
5 mg
25 mg
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Artikelnummer. Mængde
18739126 25 mg
18737426 5 mg
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Artikelnummer. 18739126 Leverandør Tocris Bioscience™ Leverandørnr. 6654/25

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Beskrivelse

NADPH oxidase (Nox) inhibitor

VAS 2870 is a NADPH oxidase (Nox) inhibitor. Inhibits PMA-stimulated oxidative burst in HL-60 cells (IC50 = 2 μM). Inhibits oxidized-LDL-mediated, but not basal, ROS production in HUVECs in vitro. Also inhibits PDGF-mediated Nox activation and ROS formation in vascular smooth muscle cells (VSMCs) and abolishes PDGF-dependent migration of VSMCs, while having no effect on proliferation. Enhances TGF-β-induced apoptosis of liver tumor cells. Also inhibits platelet aggregation through a NOX-independent mechanism.
TRUSTED_SUSTAINABILITY

Tekniske data

Kemisk navn eller materiale 7-(2-Benzoxazolylthio)-3-(phenylmethyl)-3H-1,2,3-triazolo[4,5-d]pyrimidine
CAS 722456-31-7
Mængde 25 mg
Molekylær formel C18H12N6OS
Formel vægt 360.39
Renhed 98%
Produkttitel
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